Literature review of novel biomarkers predicting CS-AKI in neonates
| Author, year | Population | AKI definition | Novel biomarkers predicting CS-AKI |
| Krawczeski et al, 201116 | 35/375 | AKIN | uNGAL, sNGAL |
| Cantinotti et al, 201217 | 26/135 | AKIN | uNGAL, BNP, uNGAL/urinary creatinine ratio |
| Ricci et al, 201218 | 50/160 | RIFLE | uNGAL |
| Peco-Antić et al, 201223 | 20/112 | ≥25% decrease in eCCl | sCys C, sNGAL, uNGAL, uKIM-1, uL-FABP |
| Hassinger et al, 201231 | 100* | RIFLE | sCys C |
| Zappitelli et al, 201241 | 294* | AKIN | Urine albumin to creatinine ratio |
| Hazle et al, 201324 | 42* | AKIN/KDIGO | uNGAL, uIL-18, uKIM-1, sCys C |
| Seitz et al, 201332 | 139* | RIFLE | uNGAL, sCys C |
| Zheng et al, 201335 | 58* | AKIN | uMA, NAG and α1-MG-MG, uNGAL and uIL-18 |
| Mamikonian et al, 201419 | 40* | RIFLE | uNGAL |
| Alcaraz et al, 201420 | 106* | RIFLE | uNGAL, uNGAL/Cr |
| Bojan et al, 201621 | 75/200 | AKIN | uNGAL, urine creatinine normalized uNGAL |
| Herbert et al, 201522 | 17* | RIFLE | uNGAL, sCys C |
| Tew et al, 201740 | 187/814 | AKIN | Nadir value of platelet |
| Reiter et al, 201826 | 59* | RIFLE | uNGAL |
| Gist et al, 201827 | 31* | KDIGO | uTIMP2*IGFBP-7, uKIM-1 |
| Burra et al, 201838 | 51* | KDIGO | Serum phosphorus |
| Volovelsky et al, 201839 | 81* | KDIGO | Serum FGF23 |
| Schroeder et al, 201925 | 30 | KDIGO | sNGAL |
The population enrolled in the studies is presented as neonate/total cases.
*Specific number of neonates was not described in the study.
AKI, acute kidney injury; AKIN, Acute Kidney Injury Network; BNP, brain natriuretic peptide; BNP, brain natriuretic peptide ; CS-AKI, acute kidney injury after cardiac surgery; eCCI, estimated creatinine clearance; FGF23, fibroblast growth factor 23; IGFBP-7, insulin-like growth factor-binding protein type 7; KDIGO, Kidney Disease: Improving Global Outcomes; α1-MG, α1-microglobulin; RIFLE, Risk, Injury, Failure, Loss, and End-Stage Kidney Disease; sCys C, serum cystatin C; sNGAL, serum neutrophil gelatinase-associated lipocalin; uIL-18, urinary IL-18; uKIM-1, urinary KIM-1; uL-FABP, urinary L-FABP; uMA, urinary microalbumin; uNGAL, urinary neutrophil gelatinase-associated lipocalin; uTIMP2, urinary tissue inhibitor metalloproteinase type 2.