RT Journal Article
SR Electronic
T1 Factors associated with mortality in congenital malformations of the gastrointestinal tract in a tertiary center in Senegal
JF World Journal of Pediatric Surgery
JO World Jnl Ped Surgery
FD BMJ Publishing Group Ltd
SP e000463
DO 10.1136/wjps-2022-000463
VO 6
IS 1
A1 Zeng, Florent Tshibwid A
A1 Mbaye, Papa Alassane
A1 Gueye, Doudou
A1 Seck, Ndèye Fatou
A1 Wellé, Ibrahima Bocar
A1 Niang, Rosalie
A1 Diedhiou, Youssouph
A1 Fall, Mbaye
A1 Ndoye, Ndèye Aby
A1 Sagna, Aloïse
A1 Ndour, Oumar
A1 Ngom, Gabriel
YR 2023
UL http://wjps.bmj.com/content/6/1/e000463.abstract
AB Objective Patients with congenital malformations (CMs) of the gastrointestinal tract (GIT) have a very high mortality. However, the literature on the factors associated with mortality in these patients is scarce in sub-Saharan Africa. The aim of this study is to identify independent risk factors for mortality in patients with CMs of the GIT at our pediatric surgical department.Methods We conducted a retrospective analysis of cases with CMs of the GIT managed at a tertiary center from 2018 to 2021. Patients were subdivided into two groups based on the outcomes, and variables with a significant difference were analyzed by logistic regression.Results Our review included 226 patients, 63 of whom died (27.88%). Patient age ranged from 0 to 15 years. Taking into account statistical significance, mortality was more frequent in neonates than in older patients (57.30% vs 6.15%), in patients coming out of the Dakar area than in those from the Dakar area (43.75% vs 19.18%), in patients with abnormal prenatal ultrasound than in those with normal ultrasound (100% vs 26.67%), in premature children than in those born at term (78.57% vs 21.87%), in patients with an additional malformation than in those with an isolated malformation (69.23% vs 25.35%), and in those with intestinal, esophageal, duodenal and colonic atresia than in those with other diagnoses (100%, 89%, 56.25% and 50%, respectively). Referred patients died more than those who changed hospitals or came from home (55.29% vs 25% and 9.09%, respectively). On multivariable logistic regression, two independent factors of mortality were identified: presence of associated malformation [odds ratio (OR)=13.299; 95% Confidence interval (CI) 1.370 to 129.137] and diagnosis of esophageal atresia (OR=46.529; 95% CI 5.828 to 371.425).Conclusion The presence of an associated malformation or diagnosis of esophageal atresia increases mortality in patients with CMs of the GIT in our environment.Data are available upon reasonable request.