PT  - JOURNAL ARTICLE
AU  - Zeng, Florent Tshibwid A
AU  - Mbaye, Papa Alassane
AU  - Gueye, Doudou
AU  - Seck, Ndèye Fatou
AU  - Wellé, Ibrahima Bocar
AU  - Niang, Rosalie
AU  - Diedhiou, Youssouph
AU  - Fall, Mbaye
AU  - Ndoye, Ndèye Aby
AU  - Sagna, Aloïse
AU  - Ndour, Oumar
AU  - Ngom, Gabriel
TI  - Factors associated with mortality in congenital malformations of the gastrointestinal tract in a tertiary center in Senegal
AID  - 10.1136/wjps-2022-000463
DP  - 2023 Jan 01
TA  - World Journal of Pediatric Surgery
PG  - e000463
VI  - 6
IP  - 1
4099  - http://wjps.bmj.com/content/6/1/e000463.short
4100  - http://wjps.bmj.com/content/6/1/e000463.full
SO  - World Jnl Ped Surgery2023 Jan 01; 6
AB  - Objective Patients with congenital malformations (CMs) of the gastrointestinal tract (GIT) have a very high mortality. However, the literature on the factors associated with mortality in these patients is scarce in sub-Saharan Africa. The aim of this study is to identify independent risk factors for mortality in patients with CMs of the GIT at our pediatric surgical department.Methods We conducted a retrospective analysis of cases with CMs of the GIT managed at a tertiary center from 2018 to 2021. Patients were subdivided into two groups based on the outcomes, and variables with a significant difference were analyzed by logistic regression.Results Our review included 226 patients, 63 of whom died (27.88%). Patient age ranged from 0 to 15 years. Taking into account statistical significance, mortality was more frequent in neonates than in older patients (57.30% vs 6.15%), in patients coming out of the Dakar area than in those from the Dakar area (43.75% vs 19.18%), in patients with abnormal prenatal ultrasound than in those with normal ultrasound (100% vs 26.67%), in premature children than in those born at term (78.57% vs 21.87%), in patients with an additional malformation than in those with an isolated malformation (69.23% vs 25.35%), and in those with intestinal, esophageal, duodenal and colonic atresia than in those with other diagnoses (100%, 89%, 56.25% and 50%, respectively). Referred patients died more than those who changed hospitals or came from home (55.29% vs 25% and 9.09%, respectively). On multivariable logistic regression, two independent factors of mortality were identified: presence of associated malformation [odds ratio (OR)=13.299; 95% Confidence interval (CI) 1.370 to 129.137] and diagnosis of esophageal atresia (OR=46.529; 95% CI 5.828 to 371.425).Conclusion The presence of an associated malformation or diagnosis of esophageal atresia increases mortality in patients with CMs of the GIT in our environment.Data are available upon reasonable request.