RT Journal Article
SR Electronic
T1 <em>VEGFA</em> rs3025039 and biliary atresia susceptibility in Chinese population: a systematic review and meta-analysis
JF World Journal of Pediatric Surgery
JO World Jnl Ped Surgery
FD BMJ Publishing Group Ltd
SP e000344
DO 10.1136/wjps-2021-000344
VO 5
IS 1
A1 He, Shiwei
A1 Yang, Yifan
A1 Meng, Lingdu
A1 Chen, Gong
A1 Huang, Yanlei
A1 Shen, Zhen
A1 Dong, Rui
A1 Zheng, Shan
YR 2022
UL http://wjps.bmj.com/content/5/1/e000344.abstract
AB Background Previous studies have suggested an association between vascular endothelial growth factor A (VEGFA) rs3025039 polymorphism and biliary atresia (BA). However, this conclusion is controversial and there is no published pooled evidence of this association.Methods This study was conducted and reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The protocol was registered with PROSPERO (International Prospective Register of Systematic Reviews). A thorough search was performed on databases including PubMed, Embase, and Chinese Biomedical Database up to August 2020. This study included 846 cases of BA and 2821 controls concerning VEGFA rs3025039 polymorphism. We selected relevant studies based on the following inclusion criteria: (1) the study design was case–control and cohort and (2) the patients carried standard clinical diagnoses of BA, etc. The exclusion criteria were as follows: (1) patients with other related diseases, (2) lack of requisite information and (3) duplicate data. The OR (odd ratio) and the corresponding 95% CI (confidence interval) were calculated to estimate the association.Results This study on VEGFA rs3025039 polymorphism in the Chinese population included 846 cases and 2821 controls. The results showed that there was no significant association between rs3025039 and susceptibility to BA under four genetic models. The results of the subgroup analysis were similar to the overall results.Conclusions This meta-analysis shows that rs3025039 was not associated with susceptibility to BA in the Chinese population. Further validation may entail additional research.PROSPERO registration number CRD42020203812.Data are available in a public, open access repository. As a meta-analysis, all of the data in this study can be found in table 1 and were extracted from the original studies.