RT Journal Article
SR Electronic
T1 Applications and prospects of targeted therapy for neuroblastoma
JF World Journal of Pediatric Surgery
JO World Jnl Ped Surgery
FD BMJ Publishing Group Ltd
SP e000164
DO 10.1136/wjps-2020-000164
VO 3
IS 2
A1 Wang, Jing
A1 Yao, Wei
A1 Li, Kai
YR 2020
UL http://wjps.bmj.com/content/3/2/e000164.abstract
AB Background Neuroblastoma is an extremely malignant tumor in children. For advanced or recurrent cases, existing treatment modalities are limited and efficacy remains disappointing. With the improvement in understanding of molecular biology of neuroblastoma and the development of clinical trials of targeted drug therapy, a variety of targeted therapies for neuroblastoma have appeared.Data sources All the recent literatures on targeted therapies of neuroblastoma on PubMed were searched and reviewed.Results This article reviewed targeted therapies of neuroblastoma going through clinical trials and obtained preliminary results. The features, advantages and disadvantages of targeted radiation therapy,immunotherapy, gene and pathway molecular inhibitor and angiogenesis inhibitor were discussed.Conclusion This study provides references for better understanding the current progress of targeted therapies for neuroblastoma.