RT Journal Article
SR Electronic
T1 Predictors of surgical complications in boys with hypospadias: data from an international registry
JF World Journal of Pediatric Surgery
JO World Jnl Ped Surgery
FD BMJ Publishing Group Ltd
SP e000599
DO 10.1136/wjps-2023-000599
VO 6
IS 4
A1 Scougall, Kathryn
A1 Bryce, Jillian
A1 Baronio, Federico
A1 Boal, Rachel L
A1 Castera, Jose Roberto
A1 Castro, Sebastián
A1 Cheetham, Tim
A1 Costa, Eduardo Corrêa
A1 Darendeliler, Feyza
A1 Davies, Justin H
A1 Dirlewanger, Mirjam
A1 Gazdagh, Gabriella
A1 Globa, Evgenia
A1 Guerra-Junior, Gil
A1 Guran, Tulay
A1 Herrmann, Gloria
A1 Holterhus, Paul-Martin
A1 Akgül, Ahsen Karagözlü
A1 Markosyan, Renata
A1 McElreavey, Kenneth
A1 Miranda, Marcio Lopes
A1 Nordenstrom, Anna
A1 O’Toole, Stuart
A1 Poyrazoglu, Sukran
A1 Russo, Gianni
A1 Schwitzgebel, Valerie
A1 Stancampiano, Marianna
A1 Steigert, Michael
A1 Ahmed, S Faisal
A1 Lucas-Herald, Angela K
YR 2023
UL http://wjps.bmj.com/content/6/4/e000599.abstract
AB Background Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence.Methods Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher’s exact tests and spearman’s correlation tests were performed on the data to assess associations between clinical factors and complication rates.Results Of the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications.Conclusions Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation.Data are available upon reasonable request.